On Friday, November 19, 2021, the U.S. Food and Drug Administration amended the emergency use authorizations (EUA) for both the Moderna and Pfizer-BioNTech COVID-19 vaccines authorizing use of a single booster dose for all individuals 18 years of age and older after completion of primary vaccination with any FDA-authorized or approved COVID-19 vaccine.

For Moderna and Pfizer-BioNTech COVID-19 vaccines, a single COVID-19 vaccine booster dose is recommended 6 months after completion of an mRNA primary series. The Moderna booster dose is a smaller 50 microgram dose.

For Janssen (Johnson & Johnson) COVID-19 vaccine, a single COVID-19 vaccine booster dose is recommended for people aged 18 years and older, 2 months after receipt of the initial Johnson & Johnson dose, under the FDA’s Emergency Use Authorization.

Eligible individuals may choose which vaccine they receive as a booster dose. Some people may have a preference for the vaccine type that they originally received and others may prefer to get a different booster. CDC’s recommendations now allow for this type of mix and match dosing for booster shots.